PittsburghV1, France, Analysis, bibRecord, 000263

Control of the Nigrostriatal Dopamine Neuron Activity and Motor Function by the Tail of the Ventral Tegmental Area

Identifieur interne : 000263 ( France/Analysis ); précédent : 000262; suivant : 000264

Control of the Nigrostriatal Dopamine Neuron Activity and Motor Function by the Tail of the Ventral Tegmental Area

Auteurs : Romain Bourdy [France] ; María-José Sánchez-Catalán [France] ; Jennifer Kaufling [France] ; Judith J. Balcita-Pedicino [États-Unis] ; Marie-José Freund-Mercier [France] ; Pierre Veinante [France] ; Susan R. Sesack [États-Unis] ; François Georges [France] ; Michel Barrot [France]

Source :

Neuropsychopharmacology [ 0893-133X ] ; 2014.

RBID : PMC:4200489

Descripteurs français

English descriptors

KwdEn :
- Animals, Central Nervous System Stimulants (pharmacology), Dextroamphetamine (pharmacology), Dopaminergic Neurons (drug effects), Dopaminergic Neurons (physiology), Learning (physiology), Male, Microelectrodes, Microscopy, Electron, Neural Inhibition (physiology), Neural Pathways (anatomy & histology), Neural Pathways (drug effects), Neural Pathways (physiology), Neuroanatomical Tract-Tracing Techniques, Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Rats, Sprague-Dawley, Rotation, Substantia Nigra (anatomy & histology), Substantia Nigra (drug effects), Substantia Nigra (physiology), Ventral Tegmental Area (anatomy & histology), Ventral Tegmental Area (drug effects), Ventral Tegmental Area (physiology).
MESH :
- chemical , pharmacology : Central Nervous System Stimulants, Dextroamphetamine.
- anatomy & histology : Neural Pathways, Substantia Nigra, Ventral Tegmental Area.
- drug effects : Dopaminergic Neurons, Neural Pathways, Psychomotor Performance, Substantia Nigra, Ventral Tegmental Area.
- physiology : Dopaminergic Neurons, Learning, Neural Inhibition, Neural Pathways, Psychomotor Performance, Substantia Nigra, Ventral Tegmental Area.
- Animals, Male, Microelectrodes, Microscopy, Electron, Neuroanatomical Tract-Tracing Techniques, Rats, Sprague-Dawley, Rotation.

Abstract

Midbrain dopamine neurons are implicated in various psychiatric and neurological disorders. The GABAergic tail of the ventral tegmental area (tVTA), also named the rostromedial tegmental nucleus (RMTg), displays dense projections to the midbrain and exerts electrophysiological control over dopamine cells of the VTA. However, the influence of the tVTA on the nigrostriatal pathway, from the substantia nigra pars compacta (SNc) to the dorsal striatum, and on related functions remains to be addressed. The present study highlights the role played by the tVTA as a GABA brake for the nigrostriatal system, demonstrating a critical influence over motor functions. Using neuroanatomical approaches with tract tracing and electron microscopy, we reveal the presence of a tVTA–SNc–dorsal striatum pathway. Using in vivo electrophysiology, we prove that the tVTA is a major inhibitory control center for SNc dopamine cells. Using behavioral approaches, we demonstrate that the tVTA controls rotation behavior, motor coordination, and motor skill learning. The motor enhancements observed after ablation of the tVTA are in this regard comparable with the performance-enhancing properties of amphetamine, a drug used in doping. These findings demonstrate that the tVTA is a major GABA brake for nigral dopamine systems and nigrostriatal functions, and they raise important questions about how the tVTA is integrated within the basal ganglia circuitry. They also warrant further research on the tVTA's role in motor and dopamine-related pathological contexts such as Parkinson's disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200489

DOI: 10.1038/npp.2014.129
PubMed: 24896615
PubMed Central: 4200489

Affiliations:

France, États-Unis

Links to Exploration step

PMC:4200489

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Midbrain dopamine neurons are implicated in various psychiatric and neurological disorders. The GABAergic tail of the ventral tegmental area (tVTA), also named the rostromedial tegmental nucleus (RMTg), displays dense projections to the midbrain and exerts electrophysiological control over dopamine cells of the VTA. However, the influence of the tVTA on the nigrostriatal pathway, from the substantia nigra pars compacta (SNc) to the dorsal striatum, and on related functions remains to be addressed. The present study highlights the role played by the tVTA as a GABA brake for the nigrostriatal system, demonstrating a critical influence over motor functions. Using neuroanatomical approaches with tract tracing and electron microscopy, we reveal the presence of a tVTA–SNc–dorsal striatum pathway. Using <italic>in vivo</italic>
 electrophysiology, we prove that the tVTA is a major inhibitory control center for SNc dopamine cells. Using behavioral approaches, we demonstrate that the tVTA controls rotation behavior, motor coordination, and motor skill learning. The motor enhancements observed after ablation of the tVTA are in this regard comparable with the performance-enhancing properties of amphetamine, a drug used in doping. These findings demonstrate that the tVTA is a major GABA brake for nigral dopamine systems and nigrostriatal functions, and they raise important questions about how the tVTA is integrated within the basal ganglia circuitry. They also warrant further research on the tVTA's role in motor and dopamine-related pathological contexts such as Parkinson's disease.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Bourdy, Romain" sort="Bourdy, Romain" uniqKey="Bourdy R" first="Romain" last="Bourdy">Romain Bourdy</name>
</noRegion>
<name sortKey="Barrot, Michel" sort="Barrot, Michel" uniqKey="Barrot M" first="Michel" last="Barrot">Michel Barrot</name>
<name sortKey="Bourdy, Romain" sort="Bourdy, Romain" uniqKey="Bourdy R" first="Romain" last="Bourdy">Romain Bourdy</name>
<name sortKey="Freund Mercier, Marie Jose" sort="Freund Mercier, Marie Jose" uniqKey="Freund Mercier M" first="Marie-José" last="Freund-Mercier">Marie-José Freund-Mercier</name>
<name sortKey="Freund Mercier, Marie Jose" sort="Freund Mercier, Marie Jose" uniqKey="Freund Mercier M" first="Marie-José" last="Freund-Mercier">Marie-José Freund-Mercier</name>
<name sortKey="Georges, Francois" sort="Georges, Francois" uniqKey="Georges F" first="François" last="Georges">François Georges</name>
<name sortKey="Georges, Francois" sort="Georges, Francois" uniqKey="Georges F" first="François" last="Georges">François Georges</name>
<name sortKey="Kaufling, Jennifer" sort="Kaufling, Jennifer" uniqKey="Kaufling J" first="Jennifer" last="Kaufling">Jennifer Kaufling</name>
<name sortKey="Kaufling, Jennifer" sort="Kaufling, Jennifer" uniqKey="Kaufling J" first="Jennifer" last="Kaufling">Jennifer Kaufling</name>
<name sortKey="Sanchez Catalan, Maria Jose" sort="Sanchez Catalan, Maria Jose" uniqKey="Sanchez Catalan M" first="María-José" last="Sánchez-Catalán">María-José Sánchez-Catalán</name>
<name sortKey="Veinante, Pierre" sort="Veinante, Pierre" uniqKey="Veinante P" first="Pierre" last="Veinante">Pierre Veinante</name>
<name sortKey="Veinante, Pierre" sort="Veinante, Pierre" uniqKey="Veinante P" first="Pierre" last="Veinante">Pierre Veinante</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Balcita Pedicino, Judith J" sort="Balcita Pedicino, Judith J" uniqKey="Balcita Pedicino J" first="Judith J" last="Balcita-Pedicino">Judith J. Balcita-Pedicino</name>
</noRegion>
<name sortKey="Sesack, Susan R" sort="Sesack, Susan R" uniqKey="Sesack S" first="Susan R" last="Sesack">Susan R. Sesack</name>
</country>
</tree>
</affiliations>
</record>

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Control of the Nigrostriatal Dopamine Neuron Activity and Motor Function by the Tail of the Ventral Tegmental Area

Control of the Nigrostriatal Dopamine Neuron Activity and Motor Function by the Tail of the Ventral Tegmental Area

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